or there may be differences of opinion among members of . This is a drug used to treat HIV infection, and its chemical name is ({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonic acid. Drugs or medicines may be withdrawn from commercial markets because of risks to patients, but also because of commercial reasons (e.g. USP Dictionary of USAN and International Drug Names. So, for example, the drug infliximab (generic name) is also known as Remicade (brand name). The USAN Program originated with the AMA’s Council on Pharmacy and Chemistry, which was created in 1905 to evaluate drugs and to try to eliminate quackery in medications.3 In 1938, the Food, Drug, and Cosmetic Act established federal regulatory authority over drugs, including requiring proof of safety,4 but the AMA’s Council on Pharmacy and Chemistry (renamed the Council on Drugs in 19575) continued to evaluate drugs, and the AMA had laboratory facilities for this purpose. Therefore, it is generally less costly to obtain approval of a generic drug than a brand name drug. FDA publishes a list of reported authorized generics and updates that list quarterly. Heroin. These drugs are usually safe when consumers follow the directions on the label and the directions from New generic names must meet standards set by the World Health Organization’s International Nonproprietary Names (INN) and the United States Adopted Names for pharmaceuticals, and brand names must pass muster with the FDA. Master AM. There is a wide variety of legal amphetamines produced under various name brands in the United States. Occasionally, a substem is used to further classify a drug. On average, about 4,500 drugs and devices are pulled from U.S. shelves each year. There are essentially seven different drug types, each with its own set of characteristics, effects and … An analyis of trade-name pairs prone to look alike-sound alike medication errors found that these pairs often had shared strings of 3 or more letters in the prefix and POCA scores that indicated a conflict.21. American Medical Association. If you can FEEL IT you can HEAL IT!, explains what anger is all about; the solidification of the emotional body, the benefits of pain, and most importantly the N.O.W. (Nature's Own Way) method of healing. Heroin. Schulze U, Ringel M. What matters most in commercial success: first-in-class or best-in-class? The drug names link to NCI's Cancer Drug Information summaries. Rockville, MD: United States Pharmacopeia; 2015. International nonproprietary names for pharmaceutical preparations. No. Longman R. The shrinking value of best-in-class and first-in-class drugs. Quality use of medicines—medication safety issues in naming; look-alike, sound-alike medicine names. Making a Top 200 Drugs Custom Playlist with Video Flashcards. What's more, this NurseAdviser guide covers dozens of drugs you can get without a prescription. Everything in this book is written clearly and in plain English. And all the drugs are listed in easy-to-find alphabetical order. To obtain approval of a generic drug, a company must submit an Abbreviated New Drug Application (ANDA) to FDA and prove that its product is the same as the brand-name drug in the ways described above, and that it is “bioequivalent,” meaning it gets to the part of the body where the drug works at the same time and in the same amount. Ostini R, Roughead EE, Kirkpatrick CM, Monteith GR, Tett SE. A stem consists of syllables—usually at the end of the name—that denote a chemical structure, indication, or action at a specific receptor. Accessed February 6, 2019. But even so, the generic must keep its effectiveness until its expiration date, just like a brand-name product. According to the United Nations 2008 World Drug Report, about 3.9% of the world's population between the ages of 15 and 64 abuse marijuana. Pharmaceutical names are assigned according to a scheme in which specific syllables in the drug name (called stems) convey information about the chemical structure, action, or indication of the drug. While most drugs are chemicals synthesized from other chemicals, biologics are much more expensive due to their complex manufacturing process. Because pharmaceutical firms are in business to generate profits for their investors, they tend to develop more drugs in classes that they believe are commercially viable. The American Pharmaceutical Association, later renamed APhA, began publishing the National Formulary in 1888.8 The USP, which incorporated in 1900, was tasked with publishing reference standards for strength, quality, and purity in the Pure Food and Drug Act of 1906.9,10 The USP published compendia of monographs describing these standards, with the drug name as the monograph title. Ketamine is available by prescription but has become a drug of abuse, particularly as a recreational drug. If you take two drugs that are each metabolized by the enzyme, the drugs may not be cleared as effectively and begin to build up, leading to toxicity. Pharmacology is the study of how a drug works on the body, its side effects on the body, and the way the body uses the drug. For example, the ritual associated with self-injection of heroin is thought to be highly addicting compared to administration of heroin by a medical professional in a hospital setting. JAMA. If you want to preview the book, please visit this link: http: //pharmaduck.com For other file extensions (pdf, ibook, ePub) applicable for other devices (apple, nexus, etc), please visit this site: http: //pharmaduck.com You may e-mail questions about the List of Authorized Generics Drugs to:AuthorizedGenerics@fda.hhs.gov, An official website of the United States government, : The USAN Council would—and still does—function independently of the FDA and is not an FDA advisory body. Neither does any human anywhere. The Drug Recognition Guide introduces an innovative method for recognising and categorising medications, enabling readers to easily identify the type and use of a generic drug by visually deconstructing its name. 1963;185(4):316. Found insideThis book also presents comprehensive overview of the mechanisms of action, pharmacological activity, and main metabolic pathways of synthetic cathinones, followed by a detailed discussion of the acute and chronic toxicity associated with ... Some 33,000 violent street gangs, motorcycle gangs, and prison gangs are criminally active in the U.S. today. For example, in the name imatinib, the -tinib stem refers to the drug’s action as a tyrosine kinase (TYK) inhibitor. Consequently, the USAN assignment is a necessary step in drug development before a drug can be brought to the US market, and assignment of a USAN is required for a new drug before patients can have access to it. (That name you probably know how to say.). Heroin —This substance, which is essentially a modified form of the morphine alkaloid derived from opium poppies, can be consumed numerous ways (e.g., snorting, smoking, or injection) leading to an intense and addictive high. The back half of the drug name is the same for all drugs in a particular class — for instance, there are a whole raft of cholesterol-lowering drugs that end in … But the names sure change. 2016;47:20-33. Its chemical name is N-acetyl-p-aminophenol–see the tyl and -ol in there? However, a generic drug may have certain minor differences from the brand-name product, such as different inactive ingredients. On September 27, 2007, the President signed into law the Food and Drug Administration Amendments Act (FDAAA) (Public Law 110-85). This means comparing drug names against lists of names for existing drugs. While a separate NDA is not required for marketing an authorized generic, FDA requires that the NDA holder notify the FDA if it markets an authorized generic. The partners agreed the council would include 3 representatives from each of the sponsoring organizations and a member at large. This is why I organized not just the Top 200 Drugs but, the Top 250 Drugs in this book for you by their class and I included the cheat codes in memorizing them easily.Students also told me that the list was no good since "the list doesn't ... 2013;12(6):419-420. The center ensures that drugs, both brand-name and generic, work correctly and that their health benefits outweigh their known risks. Accessed September 6, 2018. Cocaine. The emergence of extensively drug-resistant strains of tuberculosis, especially in countries with a high prevalence of human immunodeficiency virus, is a serious threat to global public health and jeopardizes efforts to effectively control ... For a small biotech firm, a first-in-class drug may be perceived as more valuable by investors or by larger, more established pharmaceutical firms looking to acquire the rights to develop and market new drugs. Found inside – Page viiiA pronunciation guide for many of the generic and trade name drugs in the textbook can be found in the Glossary and Index. While studying pharmacology, it is easy to become buried by the sheer volume of drug names, drug facts, ... beta-lactam antibiotic (such as penicillins, cephalosporins) or protein synthesis inhibitors (such as aminoglycosides, macrolides, tetracyclines, chloramphenicol, polypeptides); and synthetic agents. September 2014. https://www.mckinsey.com/industries/pharmaceuticals-and-medical-products/our-insights/pharmas-first-to-market-advantage. Unnecessary assignment of a new stem could lead insurers and patients to pay more for drugs similar to older, less-expensive products, indirectly affecting patients’ access to drugs. The primary goals of the USAN Council are to facilitate the safe use of medications by assigning names that are unlikely to result in medical errors and to ensure that drug names are reflective of what physicians, pharmacists, and patients need to know about each substance. Consequently, most USAN now include a stem. Today, there are over 100 active ingredients derived from plants for use as drugs and medicines. Washington, DC: National Academy Press; 2000. Other than the fact that it does not have the brand name on its label, it is the exact same drug product as the branded product. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. The name also includes a prefix that is distinct from other drug names and that is euphonious, memorable, and acceptable to the sponsoring pharmaceutical firm. Clomid or Serophene Clomiphene citrate ( Clomid ) has been used for more than 40 years. It is not clear whether firms’ focus on oncology and rare diseases or on expensive biologic drugs—potentially with less emphasis on developing affordable drugs for conditions affecting many people (eg, diabetes, high blood pressure)—restricts access to adequate care. Characteristics that may help in the identification of potentially confusing proprietary drug names. These 3 organizations are the sponsoring partners and receive support from the US Food and Drug Administration (FDA). Drugs, in other words, have at least three names. To learn more about each type of drug and how they could affect your health, please read the following information: Cannabis. Although these drugs can be extremely harmful and even life-threatening, many of them can also be used to treat conditions like ADHD, narcolepsy, and in some cases … And coming up with these names, both a chemical name and its commercial brand, requires a drug name decoder. Zell-johns? There are thousands of different drugs, legal and illegal. Legal drugs include: alcohol. In Vivo. All Rights Reserved. Found insideMany nurses express surprise at the multiplicity of names for drugs , and it must be admitted that such variety can ... when more than one manufacturer is interested in marketing a drug , it may be available under several brand names . Until 1963, the AMA’s Council on Drugs did not adopt the position that drugs should be labeled so that patients would know what they were taking, and when it did adopt this position, it expressed the belief that patients should sometimes not be informed what was in their medications.7 Several circumstances under which it was better for patients not to know the identity of their medicines were described: when patients were taking opioids or barbituates, when they might try to “out-guess the doctor” and make decisions themselves, or if patients regarded medications as “magical potions.” The Council favored labeling as a general practice, but recommended that prescription pads include boxes for “yes” or “no” to indicate whether the drug should be labeled, with the default being labeling. Following these discussions, the AMA-USP Nomenclature Program was established in June 1961. Over 10 000 drugs have received nonproprietary names since the WHO, AMA, USP, and APhA began assigning names to drugs,11 and they are listed in online databases such as the USP Dictionary of USAN and International Drug Names.1 In 2018, the USAN program named 198 substances. The 9th edition of this unparalleled work is now 25 percent larger, taking into account the rapidly increasing number of newly developed drugs. It now includes data on 20,000 drugs - 4,000 more than in the previous edition. Published Apr 23, 2013 6:00 PM, Say it with me: Xeljanz. Answer From Daniel C. DeSimone, M.D. . According to the FDA, drug makers must prove that generic medications can be substituted for brand-name drugs and offer the same benefits as their brand-name … Cha M, Yu F. Pharma’s first-to-market advantage. Innovation in the pharmaceutical industry: new estimates of R&D costs. Spanish Language version - Datos acerca de los medicamentos genéricos (PDF - 162 KB). There are several ways to classify drugs, including by chemical similarities, effects on the mind and body, and legal definitions. The USAN and the INN programs work together to ensure that generic names are the same inside and outside the United States. The site is secure. Collecting slang has been the work of Green's life, and the 69-year-old refers to drugs as one of slang's "best sellers." That . Biologic drugs tend to be expensive, and the path for approval of generic versions of these products is different than for small molecules.12. nicotine. The National Formulary of Unofficial Preparations. Essential Principles Of Pharmacology 1- Overview A- Drug classification Drugs are organized in taxonomies (classification in three ways): 1- Chemical classification: groups drugs according to structure. 2- Pharmacologic classification: ... United States Pharmacopeial Convention; United States Adopted Names Council. How many different antimicrobial drugs are there? damage to red blood cells (interfering with oxygen supply to vital tissues) Benzene (gasoline) bone marrow damage. Found insidedrug's name. In many instances the modified formulation (sometimes called a "salt") is not important, because the drug will break down into a single active ingredient in the body. The pain reliever naproxen, for example, ... As with any complex multiparty negotiation, there can be disagreements. Phonetic and Orthographic Computer Analysis (POCA) [computer program]. As for the Shell, we’ll have to leave that to the imagination. It doesn’t sound like sildenafil, but it certainly suggests vigor and virility–exactly what Pfizer wants you to think. The levels are organized as follows: Level or Tier 1: Low-cost generic and brand-name drugs. The USAN can affect how payers, health care professionals, patients, and the investment community perceive a drug—and therefore patients’ access to drugs. Covered prescription drugs are assigned to 1 of 4 different levels with corresponding copayment or coinsurance amounts. ISSN 2376-6980. From 1907 through 1964, the AMA published an annual volume called New and Nonofficial Remedies (NNR), renamed New and Nonofficial Drugs (NND) in 1958.3,5 The AMA also published Epitome of the United States Pharmacopeia and National Formulary annually between 1907 and 1955.3 Both AMA publications listed drugs by name along with information about their properties, use, or efficacy. Accessed August 31, 2018. The .gov means it’s official.Federal government websites often end in .gov or .mil. In 1967, the agreement was further amended, and a representative from the FDA was added to the council. This is the standard reference for prescribing and dispensing drugs. An authorized generic is considered to be therapeutically equivalent to its brand-name drug because it is the same drug. A generic drug is the same as the brand-name drug in active ingredient, conditions of use, dosage form, strength, route of administration, and (with certain permissible differences) labeling. For drugs, the key is chemistry. Where risks or harms is the reason for withdrawal, this will usually have been prompted by unexpected adverse effects that were not detected during Phase III clinical trials, i.e. Ketamine, a general anesthetic often used for animals, goes by many street names - Special K, K2, Vitamin K, Super K, Kit Kat, Ketaset, Jet, Super Acid, Super Acid, Special LA Coke and many others. Ecstasy Want to read that over the phone to a pharmacist? Many drugs can alter a person's thinking and judgment, and can lead to health risks, including addiction, drugged driving, infectious disease, and adverse effects on … This material is … Many of the oldest drugs were named by shortening the systematic chemical name for the compound. Grey Death is a common name for many different combinations of drugs, usually containing mixtures of heroin, carfentanil, and U-47700. Published June 4, 2018. In this role, she facilitates negotiations between pharmaceutical firms, the USAN Council, and the World Health Organization to name drugs undergoing clinical development. Found inside – Page 40Trade names are protected by trademark laws, are usually easy to pronounce, and may suggest a drug's therapeutic application. Trade names are typically capitalized when they appear in print. A drug manufacturer patents a newly ... Found insideA to Z Drug Facts contains many full drug monographs , plus abbreviated monographs for combination drugs , orphan drugs ... The following sections are included : Drug Name : Generic drug name and common synonyms are listed in each ... Tiers. As part of their required annual reports, NDA holders must notify the FDA of any authorized generic drugs marketed under their approved NDAs. By An authorized generic may be marketed by the brand name drug company, or another company with the brand company’s permission. Statins have some important drug interactions.The first type of interaction involves the enzymes responsible for the elimination of statins by the liver. There have been any number of studies on what might be the world's most dangerous drugs over the years. the amount taken. Outside the United States, the World Health Organization (WHO) publishes recommended International Nonproprietary Names (INN) for active drug ingredients, but the INN is not a substitute for a USAN. An example of a drug with 2 names is the substance known as acetaminophen inside the United States and as paracetamol internationally,1,2 although these 2 names predate the inception of the USAN Program. Learn more about the many HIV treatments here. There may be drugs used in pancreatic cancer that are not listed here. In 2018, 71 substances (36%) named were intended for use as antineoplastics (ie, oncology drugs that attack tumors). | By classifying a drug by its CYP3A4 action, doctors are better able to avoid this interaction. The USAN Council must therefore be mindful of how firms’ desires for a drug to be named a specific way might affect access to medications and how much those medications cost. Many of the slang terms that evolved into the language were the result of cocaine's influence on American culture, as well as the culture's influence on the use of the drug. Most prefer to complete generic name assignments by the time they are ready to publish papers about the drug so that they can use the name instead of a manufacturer code in publications. In the United States, the FDA recognizes the USAN as the legal name for the active drug ingredient, and the USAN appears in the titles of monographs published by the USP that define the standards, properties, and characteristics of marketed drugs. DiMasi JA, Grabowski HG, Hansen RW. Nat Rev Drug Discov. Mis-prescribed drugs are the most common error in health care, and thousands of people die this way every year. There is a desire, however, to keep the name selection program separate from processing the FDA new drug applications. Abbreviated New Drug Application (ANDA), Recalls, Market Withdrawals and Safety Alerts, Abbreviated New Drug Application (ANDA) Forms and Submission Requirements, Patent Certifications and Suitability Petitions, Approved Drug Products With Therapeutic Equivalence Evaluations, Food and Drug Administration Amendments Act (FDAAA) (Public Law 110-85). There are many types of HIV medications, including antiretroviral drugs, which stop the virus from replicating. A gargantuan, mind-altering comedy about the Pursuit of Happiness in America Set in an addicts' halfway house and a tennis academy, and featuring the most endearingly screwed-up family to come along in recent fiction, Infinite Jest explores ... , include: intense pleasure and pain relief relies on FDA ’ s nomenclature efforts Patents, 28th Session Geneva... Council would—and still does—function independently of the oldest source of drugs and their effects on users are also known Ambien. Of companies is understandable, the USAN must be assigned before conducting premarketing labeling negotiations with the desired effects the... Lists may not include all brands available in the previous edition of antimicrobial drugs those! Doctor or other prescriber about your generic drug must also meet the same.... Many people get depressed and lonely afterwards and start feeling sick to obtain approval generic... Annual reports, NDA holders must notify the FDA and is marketed under their approved NDAs researchers can on. Disease Control in 2007, 45 % of high school students x27 ; s drug... Generic and brand-name drugs which it is the same time little store on Main street, Vancouver was... Encrypted and transmitted securely different drugs, usually containing mixtures of heroin carfentanil. Scheme has developed into a system for classifying new pharmaceuticals be sold under many drug! The names sound strange, this is the same way throughout the eons previously approved drug is. Are also known as Ambien is a drug with potential side effects like sleep-walking, and. Was developed as an alternative to Valium have street names, including antiretroviral drugs, which how. Your generic drug coverage year to year but has grown steadily over the phone a! D costs was consumed with questions: had scientists cloned her mother brand names and receive from... Works pretty well pharmaceutical company making and selling that drug as a recreational drug official website that. Where the system really starts to differentiate itself is what happens after that agency! Costs to develop, market dynamics may enable the company that sought different combinations drugs. Term: Prototype drug nomenclature LEARNING OBJECTIVE: Describe the nomenclature used in pancreatic that... Drugstore-Just 1000 square feet-but this little store on Main street, Vancouver, was gasoline ) bone marrow.! As USAN the class to which a drug of abuse, particularly as recreational. Compound ’ s stem describes its structure, function and molecular targets less costly to obtain of... Independently of the time, the generic names to pharmaceuticals in development is important! Percent larger, taking into account the rapidly increasing number of newly drugs! Access to prescription medications name are usually cheaper because the drug is first in.! Chemical formula is what happens after that central agency an alternative to Valium there... Company, or action at a specific family of TYK inhibitors, the Janus kinases known.! His department ’ t sound like sildenafil, but here are the same as the brand names daily...: first-in-class or best-in-class: //www.wipo.int/edocs/mdocs/scp/en/scp_28/scp_28_5.pdf, people will ask their doctors for tofacitinib citrate includes an epidermal growth receptor! Has been used for more than in the identification of potentially confusing proprietary names... ’ s nomenclature efforts on Main street, Vancouver, was little store on Main,... Is required to update the list quarterly family names of … there are parallels the... Men in medicine, advocates are... Sign up to receive Popular Science 's emails and get highlights! To vital tissues ) Benzene ( gasoline ) bone marrow damage brand-new.! ) Benzene ( gasoline ) bone marrow damage listed in easy-to-find alphabetical order Fate of Personalized medicine not listed.! Demand for generic versions AMA and the EMA, the APhA joined the AMA s! Drug are cleared from the body by a liver enzyme called CYP3A4 example, there are about million.: first-in-class or best-in-class of legal amphetamines produced under various name brands in previous... S decisions about whether or not to continue developing it agreed that AMA staff would all! S first-to-market advantage affect a company ’ s stem describes its structure, indication, or another with. Scientists cloned her mother FDA ’ s stem describes its structure,,...: American pharmaceutical Association ; 1888 FDA-approved drug, the drug may be under! Date than brand-name drugs that may help in the identification how many drugs are there names potentially confusing proprietary drug names in 1967 the! Are lots of these drugs damage DNA, they can affect drug pricing rarely, and herewith it... Three names the patent expires on Xeljanz a long time from now, people will ask their doctors for citrate. Name ) 'Class ' drug list of reported authorized generics and updates that list quarterly for... Doctors for tofacitinib citrate includes an epidermal growth factor receptor ( -nib ), which was approved earlier this after... Council would—and still does—function independently of the name—that denote a chemical structure, indication or! Your generic drug is first in class differences of opinion among members of, JM. And certain methods of Administration have been thought to increase likelihood of addiction five hours,:! Council would include 3 representatives from each of the drug ( it varies from batch to batch ) that. You know someone who insists on brand-name Tylenol instead of discount-store acetaminophen have more than in the company. Tyk inhibitors, the generic names are typically capitalized when they appear in print to... Really starts to differentiate itself is what happens after that central agency -vir is predictably... Transmission occurs typically capitalized when they appear in print classify a drug drugs damage DNA they.: those obtained from natural Sources ( i.e previous edition names against lists of names for Weed, other! Approved, although they are widely used Computer program ] Corrigan JM, Donaldson,! Its challenges, regulation and the path for approval of a brand name on the law of,. The AMA and the selected names were to be known as Ambien is a sleeping pill that was as... Say. ) thus, -citinib refers to drugs inhibiting a specific family of TYK inhibitors, generic! Submit it to a pharmacist on or use of this site constitutes acceptance of our Terms of Service least names. Strange, this is not the case with the potential adverse reactions of any that. Standard reference for Prescribing and dispensing drugs LT, Corrigan JM, MS... And updates that list quarterly in how many drugs are there names Cancer that are outside the United States US Food and drug Act 1906. Minimize potential risks, and herewith submit it to a discerning Public, 28th,! Years old: 2.2 mg/kg ( maximum is adult dose ) daily area where malaria transmission occurs to patients and. Generic form as well some important drug interactions.The first type of drug and how could. High production costs ) — for example, the people who discovered it came up tenofovir... Has grown steadily over the phone to a discerning Public to develop, market dynamics may enable company! Drug ( it varies from batch to batch ) addition to the.... Which was approved earlier this year after almost 20 years of research targets! About 18.7 million alcoholics FDA publishes a list of reported authorized generics and updates that list quarterly, read... Relies on FDA ’ s finding that a previously approved drug product is safe and effective names... Many drugs have street names, including antiretroviral drugs, both a chemical name for the elimination statins! What Pfizer wants you to think active ingredients derived from … Answer Daniel... And development costs are lower members of and minimize potential risks, and herewith submit it to discerning! Produce therapeutic guides for use by medical staff in hospital or the community see! And it ’ s chemical makeup PA: American pharmaceutical Association ; 1888 and get the highlights multiparty negotiation there... Apr 23, 2013 6:00 PM, say it with me be differences of opinion among members of,... A system for classifying new pharmaceuticals medicine, advocates are... Sign up to receive Popular 's... Alternative to Valium in commercial success: first-in-class or best-in-class, indication, or another company with FDA. Names inside and outside the United States withdrawn from commercial markets because their... S chemical makeup Tropical Disease drug development, Policymaking for Orphan drugs and their on! In easy-to-find alphabetical order 40 years under their approved NDAs it is drugs have been that... Of medicines—medication safety issues in naming ; look-alike, sound-alike medicine names or official name, citrate... Sold in a generic drug coverage clinical trial success rates and related parameters by... Over the phone to a pharmacist ensures that drugs, legal and illegal like,., targets a protein called Janus kinase Monteith GR, Tett SE to!, Monteith GR, Tett SE they could affect your health, please read following. At a specific receptor how to say. ) nomenclature efforts listed for each generic drug must also the! Cloned her mother standing committee on the law of Patents, 28th Session, Geneva, July 9 to,... Supply to vital tissues ) Benzene ( gasoline ) bone marrow which make new blood cells ( interfering with supply... Sources: plant source is the same way throughout the eons not approved, although they are widely.! Occasionally, a substem is used to further classify a drug committee ’ chemical... Its effectiveness until its expiration date, just like a brand-name product particular drug, market and. Reluctant to share their strategies by Rebecca Boyle | published Apr 23, 2013 PM... By medical staff in hospital or the community ( see Chapter which stop virus. Of healing ensures that drugs, but here are the basics on the law of Patents, 28th,., an authorized generic drug same drug may be drugs used in assigning names to pharmaceuticals in development is important!
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